Posted on: 20 December 2022
Modern humans evolutionarily split from our chimpanzee ancestors nearly 7 million years ago, yet we are continuing to evolve – with new analyses conducted by scientists from Trinity highlighting that two new human-specific “microgenes” have arisen from scratch.
Taking a previously published dataset of functionally relevant new genes, the scientists created an ancestral tree comparing humans to other vertebrate species. They tracked the relationship of these genes across evolution and found 155 that popped up from regions of unique DNA.
“This project started back in 2017 because I was interested in novel gene evolution and figuring out how these genes originate,” says Nikolaos Vakirlis, a scientist at the Biomedical Sciences Research Center “Alexander Fleming” in Vari, Greece, and first author of the journal article that has just been published in the journal Cell Reports.
“It was put on ice for a few years, until another study got published that had some very interesting data, allowing us to get started on this work.”
Aoife McLysaght, Professor in Trinity’s School of Genetics and Microbiology and senior author said: “It was quite exciting to be working in something so new. When you start getting into these small sizes of DNA, they're really on the edge of what is interpretable from a genome sequence, and they're in that zone where it's hard to know if it is biologically meaningful.”
Yet of the 155 new genes (some of which are ancient, some recent), 44 are associated with growth defects in cell cultures, demonstrating the importance of these genes in maintaining a healthy, living system.
Because these genes are human specific, it makes direct testing difficult. Researchers must seek another way to explore what effects these new genes may have on the body, leaving Vakirlis and his team to examine patterns found within the DNA that can hint at the roles these genes play.
Three of these 155 new genes have disease-associated DNA markers that point to connections with ailments such as muscular dystrophy, retinitis pigmentosa, and Alazami syndrome. And apart from disease, the researchers also found a new gene that is associated with human heart tissue. This gene emerged in human and chimps right after the split from gorillas and shows just how fast a gene can evolve to become essential for the body.
“It will be very interesting in future studies to understand what these microgenes might do and whether they might be directly involved in any kind of disease,” said Vakirlis.
Professor McLysaght added: “These genes are convenient to ignore because they're so difficult to study, but I think it'll be increasingly recognised that they need to be looked at and considered. If we're right in what we think we have here, there's a lot more functionally relevant stuff hidden in the human genome.”
This research was funded by the European Research Council and by Greece and the European Union.
Thomas Deane | Media Relations | [email protected] | +353 1 896 4685
