Posted on: 14 December 2012
Researchers at The Irish Longitudinal Study on Ageing (TILDA) at Trinity College Dublin have published a new report on multiple medication use in adults aged over 50 in Ireland, examining rates of polypharmacy and opportunities for cost savings using generic and reference prices.
The report was prepared using data from the first wave of The Irish Longitudinal Study on Ageing (TILDA). TILDA is a large-scale study of 8,175 people aged 50 and over and living in Ireland. Participants were first interviewed in 2010.
Polypharmacy, the regular use of five or more medicines, is very common in older people in Ireland (one in three aged over 65) and becomes more common with advancing years (table 1). Polypharmacy is important because it can put people, particularly older people, at risk of serious complications − such as falls, fractures and complications from drug interactions (confusion, delirium, strokes). The findings of this report highlight the need for frequent medications review in older adults. TILDA participants were all living in the community at the time of the report, it may be that polypharmacy is more common in older people in nursing home settings. The report’s authors were Kathryn Richardson, Patrick Moore, Jure Peklar, Kathleen Bennett and Rose Anne Kenny (all of Trinity College Dublin) and Rose Galvin (Royal College Surgeons in Ireland).
High levels of concomitant food supplement (also known as dietary supplement) use were also reported in those with polypharmacy and were more common in women (44% in women, 27% in men). Food supplements can interact with other medicines and these interactions should be discussed by pharmacists and general practitioners.
Prescribed medications can be made cheaper by prescribing generics (copies of the original medicine no longer protected by patent) or by using reference pricing (setting one price for groups of similar medicines).
Over €0.3 billion is spent each year on medicines for adults on polypharmacy over 50 years. Only one in five prescribed medicines are generic, which compares poorly with other cultures such as the US and UK. Furthermore, generic prices of commonly used medicines in Ireland are several times more expensive than their UK counterparts. Current international guidelines recommend regular medication review and substitution for a cheaper medicine with the same therapeutic outcome where possible. One of the senior authors , Professor Kathleen Bennett, commented that ” the Irish prices were substantially higher than UK counterparts, for example 2 of the 10 most commonly prescribed medicines were 6 times more expensive in Ireland.” Because only one in five medicines used by those reporting polypharmacy was a generic, in 2010, €30 million per year could have been saved by increasing the use of generic medicines (Irish generic pricing).
Based on 2010 prices, up to €152 million could have been saved annually using a system of reference pricing based on groups of similar drugs. For example, for commonly prescribed drugs such as statins for lowering cholesterol, the potential annual savings from increasing the use of generics would have been €1 million and from using reference pricing €40 million per year.
Commenting on the results, the Principal Investigator for TILDA, Professor Rose Anne Kenny said: “This report highlights the extent of the medication burden in adults in Ireland and where considerable cost savings could be made. Polypharmacy is common and potentially puts the ageing population at risk of serious complications. Given that polypharmacy accounts for over half of the annual costs of prescribed medications in the entire population aged over 50 years, review of medications and generic substitution should offer opportunities for considerable savings”.
The report is titled Polypharmacy in adults over 50 in Ireland: Opportunities for cost saving and improved healthcare. It can be downloaded from
http://www.tcd.ie/tilda/publications/reports/
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