Professor Padraic Fallon

• Schwartz, C., O'Grady, K., Lavelle, E.C., Fallon, P.G., Interleukin 33: An innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer, European Journal of Immunology, 46, (5), 2016, p1091-1100Journal Article, 2016, DOI
• Fleury, O.M., McAleer, M.A., Feuillie, C., Formosa-Dague, C., Sansevere, E., Bennett, D.E., Towell, A.M., McLean, W.H.I., Kezic, S., Robinson, D.A., Fallon, P.G., Foster, T.J., Dufrne, Y.F., Irvine, A.D., Geoghegan, J.A., Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis, Infection and Immunity, 85, (6), 2017, ppii: e00994-16Journal Article, 2017, TARA - Full Text
• Oleszycka, E., McCluskey, S., Sharp, F.A., Muoz-Wolf, N., Hams, E., Gorman, A.L., Fallon, P.G. and Lavelle EC., The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses., European Journal of Immunology, 2018, 705-715Journal Article, 2018, DOI
• Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM, 2018, p217-224Journal Article, 2018, URL , TARA - Full Text
• Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Svin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117Journal Article, 2018, DOI , URL
• Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1--Journal Article, 2019, DOI , URL , TARA - Full Text
• Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muoz-Wolf, N. and G"rtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6Journal Article, 2019, DOI , URL
• Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT., Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction., Nature communications, 10, (1), 2019, p4003Journal Article, 2019, DOI , TARA - Full Text
• Browning J, Rooney M, Hams E, Takahashi S, Mizuno S, Sugiyama F, Fallon PG, Kelly VP., Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression., Molecular biology reports, 2020Journal Article, 2020, DOI
• Carroll, A.M., Haines, L.R., Pearson, T.W., Fallon, P.G., Walsh, C.M., Brennan, C., Breen, E. & Porter, R.K., Identification of a functioning mitochondrial uncoupling protein 1 in thymus, Journal of Biological Chemistry, 280, 2005, p155534 - 155543Journal Article, 2005, DOI , TARA - Full Text
• Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211Journal Article, 2002, DOI , TARA - Full Text
• Adams AE, Carroll AM, Fallon PG, Porter RK., Mitochondrial uncoupling protein 1 expression in thymocytes., Biochimica et Biophysica Acta (BBA) - Bioenergetics , 1777, (7-8), 2008, p772 - 776Journal Article, 2008, DOI , TARA - Full Text
• Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117Journal Article, 2008, DOI , TARA - Full Text
• Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Dirdre N Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Miajlovic H, Fallon PG, Irvine AD, Foster TJ., Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus, Journal of Allergy and Clinical Immunology, 126, (6), 2011, p1184-1190Journal Article, 2011, DOI , TARA - Full Text
• Verma NK, Dempsey E, Long A, Davies A, Barry SP, Fallon PG, Volkov Y, Kelleher D, Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor- signaling., The Journal of biological chemistry, 287, (32), 2012, p27204-16Journal Article, 2012, DOI , TARA - Full Text
• Yang S, Wang B, Humphries F, Jackson R, Healy M, Bergin R, Aviello G, Hall B, McNamara D, Walsh P, Russell S, Hussey S, O'Sullivan M, Darby T, Quinlan A, Shanahan F, Melgar S,Fallon PG, Moynagh P, Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis, Nature Immunology, 14, (9), 2013, p927 - 936Journal Article, 2013, DOI , TARA - Full Text
• Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, (1), 2014, p367-72Journal Article, 2014, DOI , TARA - Full Text
• Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778Journal Article, 2014, DOI , TARA - Full Text
• O'Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, Hirani N, Hogaboam CM, Donnelly SC., The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis., Am J Respir Crit Care Med., 188, 2013, p1442 - 1450Journal Article, 2013, DOI

My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.